PLGA-Nanospheres: Delivery tools for the treatment of liver fibrosis

Aims: Liver fibrosis and cirrhosis are a common consequence of the majority of chronic liver insults and represent a common and difficult clinical challenge of worldwide importance. Significant morbidity and mortality are associated with the development of liver fibrosis, and particularly cirrhosis. Thus, there is a considerable imperative to develop antifibrotic strategies that are applicable to liver fibrosis [1]. Biodegradable Poly(D,L-lactic-co-glycolic acid) (PLGA)-nanospheres were demonstrated to be a potent deliverer for peptides, proteins or DNA. They protect the embedded devices from enzymatic degradation and release them controlled during a longer time period [2]. Our aim is to administer antifibrotic devices by biodegradable nanospheres .