Plasma-treated biomaterials

Summary form only given. Surface modification utilizing atmospheric or low pressure plasma processing can effectively enhance the properties of a myriad of biomaterials. Atmospheric pressure plasma spraying has been used to fabricate relatively thick ceramic coatings for orthopedic applications such as hip joint replacement. We have recently fabricated bioactive nanostructured titanium oxide coatings that are bioactive and conducive to the growth of apatite. The materials were synthesized by nano-particle atmospheric pressure plasma spraying followed by low pressure plasma immersion ion implantation. Surface bioactivity can also be induced by irradiating the nano-structure TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> coatings with ultraviolet light instead of hydrogen plasma ion implantation. Low pressure plasma immersion ion implantation (PIII) has been used to treat other biomaterials to enhance the surface bioactivity. This technique offers the unique advantage that the surface properties and biocompatibility of the materials can be enhanced selectively while their favorable bulk characteristics remain unchanged. For instance, mechanically sturdy materials with good wear and corrosion resistance can be modified to improve the surface bioactivity in biomedical applications. Existing materials can thus be used and need for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical implants. For instance, biological friendly elements have been plasma implanted into diamond-like carbon (DLC) and in vitro analyses reveal enhanced surface biocompatibility. The effects on the biocompatibility of novel orthopedic biomaterials such as NiTi shape memory alloys will also be discussed. Last but not least, single crystal silicon can be made bioactive by hydrogen plasma implantation. Enhancement of the surface biocompatibility of silicon is important to the development of silicon-based biosensors