Phenolic acids in the wild mushroom Ganoderma lucidum and synthesis of some possible metabolites.

Ganoderma lucidum is one of the most extensive!) studied mushrooms due to its medicinal properties, p-Hydroxybenzoic acid was the most abundant phenolic acid found in this mushroom. after HPLC-DAD-MS analysis. In the present work we describe the synthesis of glucuronide and methyl derivatives of p-hydroxybenzoic acid, which arc two of the main circulating metabolites found in humans. Their biological activity is going to be evaluated and compared to the parent compound in order to understand the in vivo mechanism of action of phenolic acids, considering their metabolism