Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

Stefano Angiari; Marah C. Runtsch; Caroline E. Sutton; Eva M. Pålsson‐McDermott; Beth Kelly; Nisha Rana; Harry Kane; Gina Papadopoulou; Erika L. Pearce; Kingston H. G. Mills; Luke O'neill

doi:10.1016/j.cmet.2019.10.015

Abstract

1 min read

Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. Here, we report PKM2 upregulation, phosphorylation, and nuclear accumulation in murine and human CD4

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