Persistence of <i>UBTF</i> tandem duplications in remission in acute myeloid leukaemia

Abstract UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF‐TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF‐ TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.