Pentraxin-3 in COPD: innocent bystander or amplifier?

Alberto Mantovani

doi:10.1183/09031936.00198111

Abstract

1 min read

In this issue of the European Respiratory Journal , Van Pottelberge et al. [1] report on the association between interstitial levels of the long pentraxin, PTX3, and chronic obstructive pulmonary disease (COPD). COPD remains a formidable challenge in terms of identifying prognostic markers and innovative therapeutic approaches. COPD is characterised by worsening lung function sustained by an unrestrained nonresolving inflammatory response. There is a need for innovative prognostic markers relevant to disease progression and its complications [2]. In this report, Van Pottelberge et al. [1] found that lower levels of PTX3 in the lung interstitium of COPD patients were associated with airway obstruction as assessed by forced expiratory volume in 1 s (FEV1). The different levels of PTX3 were not a reflection of different amounts of PTX3 mRNA transcripts, as assessed in whole tissue extracts. Sputum levels were uninformative. Unlike C-reactive protein (CRP), PTX3 levels did not increase in COPD, but a correlation between …

Related publications

Article2011

Interleukin-6, but not pentraxin 3, predicts adverse clinical outcomes on short-term prognosis of patients with incipient heart failure

Piera Boschetto, Barbara Bottazzi, Alessandro Fucili, A Potena, Licia Ballerin, Mariarita Stendardo, Simonetta Piva, Alessia Verduri, Bianca Beghé, Alberto Mantovani, Leonardo M. Fabbri, Roberto Ferrari, Claudio Ceconi

Article2015

Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients

Maurizio Infante, Paola Allavena, Cecília Garlanda, Manuela Nebuloni, Emanuela Morenghi, Daoud Rahal, Massimo Roncalli, Silvio Cavuto, Samantha Pesce, Marta Monari, Serenella Valaperta, Alessandro Montanelli, Daniel Solomon, Edoardo Bottoni, Valentina Errico, Emanuele Voulaz, Manuela Bossi, Giuseppe Chiesa, Eliseo Passera, Alberto Mantovani, Marco Alloisio

Article2013

Proteolytic cleavage of the long pentraxin PTX3 in the airways of cystic fibrosis patients

Yveline Hamon, Sébastien Jaillon, Christine Person, Jean-Louis Giniès, Erwan Garo, Barbara Bottazzi, Sarah Ghamrawi, T. Urban, Jean-François Subra, Jean-Philippe Bouchara, Alberto Mantovani, Pascale Jeannin, Yves Delneste

Dataset

Dataset related to article "Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19"

Enrico Brunetta, Marco Folci, Barbara Bottazzi, Maria De Santis, Giuseppe Gritti, Alessandro Protti, Sarah N. Mapelli, Stefanos Bonovas, Daniele Piovani, Roberto Leone, Ilaria My, Veronica Zanon, Gianmarco Spata, Monica Bacci, Domenico Supino, Silvia Carnevale, Marina Sironi, Sadaf Davoudian, Clelia Peano, Francesco Landi, Fabiano Di Marco, Federico Raimondi, Andrea Gianatti, Claudio Angelini, ,

Dataset

Pentraxin-3 in COPD: innocent bystander or amplifier?

Abstract

Discussion(0)

Related publications

Interleukin-6, but not pentraxin 3, predicts adverse clinical outcomes on short-term prognosis of patients with incipient heart failure

Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients

Proteolytic cleavage of the long pentraxin PTX3 in the airways of cystic fibrosis patients

Dataset related to article "Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19"

Dataset related to article "Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19"