Patterned nanofiber meshes for biomedical applications

The aim of this work was to prepare nanofibre meshes using various collectors with different geometries and with specific dimensions and to evaluate how those patterns can affect the properties of the meshes. The underlying hypothesis addressed in this study is if it is possible to control the architecture of the fibre meshes by tailoring the geometry of the collector. To test this hypothesis, different collectors were used. Electrospun nonwoven patterned meshes of polyethylene oxide (PEO) and poly(H-caprolactone) (PCL) were successfully prepared. Those fibre meshes were imaged with scanning electron microscopy (SEM). Both mechanical properties of the meshes and preliminary cell contacting experiments were performed to test the effect of the produced patterns over the properties of the meshes relevant for biomedical applications.