Three factors are related with the pathogenesis of venous thrombosis: (1) blood stasis, (2) hypercoagulability, and (3) vessel damage. Local and systemic factors are implicated in blood stasis. Remarkable advances have been recently achieved regarding the understanding of the concept of hypercoagulability, with special emphasis to thrombophilic molecular abnormalities. Increased thromboembolic risk has been described in patients with antithrombin III, protein C, or protein S deficiencies as well as factor V Leiden, prothrombin mutation G20210A, or hyperhomocystinemia. Vessel wall has a remarkable role in protecting against and in promoting thrombosis. The role of inflammation on venous thrombosis is under investigation.
Marlieke Visser, Rick van Minkelen, Vincent Marion, Martin den Heijer, Jeroen Eikenboom, Hans L. Vos, P. Eline Slagboom, Jeanine J. Houwing‐Duistermaat, Frits R. Rosendaal, Rogier M. Bertina
Carla Y. Vossen, Isobel D. Walker, Peter J. Svensson, Juan Carlos Souto, I. Scharrer, F E Preston, Gualtiero Palareti, Ingrid Pabinger, F.J.M. van der Meer, Michael Makris, J. Fontcuberta, Jacqueline Conard, Frits R. Rosendaal
C.Y. VOSSEN, J. Conard, J. Fontcuberta, Michael Makris, F.J.M. van der Meer, Ingrid Pabinger, Gualtiero Palareti, F E Preston, I. Scharrer, Juan Carlos Souto, Peter J. Svensson, Isobel D. Walker, Frits R. Rosendaal
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