Pathogen recognition by innate immunity and its signaling

Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.(Communicated by Tadamitsu KISHIMOTO, M.J.A.)