Paecilomycone Inhibits Quorum Sensing in Gram-Negative Bacteria

Wouter A. G. Beenker; Jelmer Hoeksma; Marie Bannier-Hélaouët; Hans Clevers; Jeroen den Hertog

doi:10.1128/spectrum.05097-22

Abstract

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Antibiotics are becoming less effective against bacterial infections due to the evolution of resistance among bacteria. Pseudomonas aeruginosa is a Gram-negative pathogen that causes major health care concerns and is difficult to treat due to its high intrinsic resistance to antimicrobial agents. Therefore, new targets are needed, and an interesting approach is to target quorum sensing (QS).

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