[P3–581]: THE IMPACT OF ADHERENCE TO MULTIDOMAIN LIFESTYLE INTERVENTION ON COGNITION: THE FINNISH GERIATRIC INTERVENTION STUDY TO PREVENT COGNITIVE IMPAIRMENT AND DISABILITY (FINGER)

FINGER is a multicenter randomized controlled trial (NCT01041989) that reported beneficial effects on cognition for a 2-year multidomain intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports the effects of intervention adherence defined as 1) participation in proposed intervention activities and 2) adherence to brain healthy lifestyle, on change in cognition. FINGER targeted 1260 at-risk elderly from the general Finnish population, aged 60–77 years and without dementia/substantial cognitive impairment. Primary outcome was change in cognition (Neuropsychological Test battery, NTB z-score). The participation in each intervention domain was defined as low (no participation, score=0), medium (1–50 % of the proposed activities=1), or high (at least 50 % =2). The overall participation was calculated as a sum of the participation scores to each domain (range 0–8) Adherence to brain healthy lifestyle, including 4 components, was calculated for both intervention and control groups based on 3-day food records (diet), Minnesota questionnaire (physical activity), leisure-time social and cognitive activities (cognitive component), and FINRISK score (vascular component). Change in each adherence component during the 2 years was categorized as: decline (score -1), stable (score 0), improvement (score 1), and summed to have an indicator of overall change in brain healthy lifestyle (range -4 to +4). Overall, the participation in the intervention activities was high. For diet and vascular components, 90 % had high participation. Participation was somewhat lower in exercise and cognitive training components that required continuous activity, with 50 % having high participation. More active participation in the multidomain lifestyle intervention had a beneficial effect on the change in cognition (p<0.01, adjusted for baseline cognition, sociodemographic, lifestyle and health factors). The overall brain-healthy lifestyle was improved more in the intervention group compared with the control group (p=0.01). Positive lifestyle changes were linked to positive changes in cognition during the intervention (p=0.02, adjusted analyses). Older adults participate actively in intensive multidomain intervention and the participation influences the impact of the intervention on cognition. The intervention also results in improvement in overall brain healthy lifestyle. Achieved positive lifestyle changes benefit cognition.