Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

Paola Costantini; Anne-Sophie Belzacq; Helena L.A. Vieira; Nathanaël Larochette; Manuel A. de Pablo; Naoufal Zamzami; Santos A. Susín; Catherine Brenner; Guido Guido Kroemer

doi:10.1038/sj.onc.1203299

Related publications

Article2000

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

Naoufal Zamzami, Isabel Marzo, Zhihua Xie, Brian Leber, David W. Andrews, Hervé Duclohier, John C. Reed, Guido Guido Kroemer, Catherine Brenner, Hervé Cadiou, Helena L.A. Vieira

Article2001

Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target.

A-S Belzacq, E Jacotot, Helena L.A. Vieira, D Mistro, David J. Granville, Zhihua Xie, John C. Reed, Guido Guido Kroemer, Catherine Brenner

Article1999

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

L Ravagnan, Isabel Marzo, Paola Costantini, Santos A. Susín, Naoufal Zamzami, Patrice X. Petit, François Hirsch, Marc Goulbern, M.F. Poupon, Laurent Miccoli, Zhihua Xie, John C. Reed, Guido Guido Kroemer

Article1998

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

Isabel Marzo, Catherine Brenner, Naoufal Zamzami, Santos A. Susín, Gisela Beutner, Dieter Brdiczka, René Rémy, Zhihua Xie, John C. Reed, Guido Guido Kroemer

Article1998

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

Naoufal Zamzami, Isabel Marzo, Santos A. Susín, Catherine Brenner, Nathanaël Larochette, Philippe Marchetti, John Reed, Reinhard Kofler, Guido Guido Kroemer