Other Transcription Factor Families

Gregg L. Friedman

doi:10.1093/oso/9780195112399.003.0012

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Gregg L. Friedman

Johns Hopkins University

Other Transcription Factor Families

Chapter In A Book 1998 en

Authors

Gregg L. Friedman
Johns Hopkins University

Abstract

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Abstract In addition to the zinc finger, PAX, bHLH, homeodomain, HMG, and POU proteins described in the preceding seven chapters, other transcription factor families have been identified that utilize unique DNA-binding domains. Members of such families that have been implicated in genetic disorders, including the TBX and RFX family members, are described in this chapter. Finally, HNF-lcx and HNF-4 are the homeodomain and nu clear receptor proteins, respectively. Because these two transcription factors interact genetically, both in normal development and in the pathogenesis of diabetes, they will be described together in this chapter.