Organic dots composed of emissive aggregates of aggregation-induced emission (AIE) luminogens and biocompatible polymeric matrices are emerging as promising reagents for bioimaging, owing to various merits including strong photoluminescence, high photostability, low toxicity and facile functionalization. On page 6430, X. Lou, Z. Zhao, and B. Z. Tang present the excellent performances of AIE dots in two-photon fluorescence in vitro cellular imaging and in vivo deep-tissue visualization.
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