Optimization of cervical cord atrophy measurement using a real-world, multicentre dataset in multiple sclerosis

Carsten Lukas; Barbara Bellenberg; Ferran Prados; Paola Valsasina; Katrin Parmar; Iman Brouwer; Deborah Pareto; Àlex Rovira; Jaume Sastre‐Garriga; Claudia A. M. Gandini Wheeler‐Kingshott; Michael A�mann; Maria A. Rocca; Massimo Filippi; Marios Yiannakas; Eva Strijbis; Frederik Barkhof; Hugo Vrenken

doi:10.3389/fneur.2025.1657484

Abstract

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Clinical performance of CSA quantification regarding discrimination between rMS and pMS and correlations with EDSS was better for whole cervical cord (C1-7) than for C1-2 measurements, and for normalization by C1-C2 or C1-C3 vertebral height. Based on the quantitative results of this exploratory multi-center study and on previous literature, we formulated recommendations to support future study design decisions.

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