One‐Pot Selective Catalytic Synthesis of Pyrrolidone Derivatives from Ethyl Levulinate and Nitro Compounds

N-substituted 5-methyl-2-pyrrolidones were prepared in a one-pot process starting from ethyl levulinate and nitro compounds in the presence of a nanosized Pt-based catalyst. Pt supported on TiO2 nanotubes (Pt/TiO2-NT) catalyzed the synthesis of N-substituted 5-methyl-2-pyrrolidones through a cascade process involving the reduction of nitro compounds, formation of the intermediary imine, hydrogenation, and subsequent cyclization. A bifunctional metal–acid system was a suitable catalyst for the process. Pt supported on TiO2 showed lower catalytic activity than Pt/TiO2-NT owing to the strong adsorption of nitro compounds during the first reaction step that poisoned the acidic sites and strongly decreased the rate of amination and cyclization. However, Pt/TiO2-NT with milder acid sites was less affected by the adsorption of nitro compounds and the full cascade process could proceed. The results indicate that the prepared Pt/TiO2-NT is a chemoselective and reusable catalyst that can be applied to the synthesis of a variety of N-substituted 5-methyl-2-pyrrolidones starting from nitro compounds with excellent yields in absence of an additional organic solvent under mild reaction conditions.