Macrophages are a key component of the tumor microenvironment (TME). Blocking Clever-1, a molecule expressed in M2-like macrophages, unleashed macrophage and T-cell-mediated antitumor immunity. Myeloid checkpoints including Clever-1 hold promise as alternative or complementary immunotherapy strategies.<i>See related article by Viitala et al., p. 3289</i>.
Gabriele Galliverti, Stephan Wullschleger, Mélanie Tichet, Dhaarini Murugan, Nadine Zangger, Wesley Horton, Alan J. Korman, Lisa M. Coussens, Melody A. Swartz, Douglas Hanahan
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