An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
Nancy L. Johnson, Anne M. Gardner, Katrina Diener, Carol A. Lange, Janice Gleavy, Matthew Jarpe, Audrey Minden, Michael Karin, Leonard I. Zon, Gary L. Johnson
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