Course of illness, treatment effectiveness, and outcomes in bipolar disorder are studied in various ways, including randomized controlled clinical and pragmatic trials and observational studies. Clinical trials have important limitations that often make the application of findings difficult in real-world settings. Pragmatic trials study a treatment intervention in a more practical setting, but recent pragmatic trials of bipolar disorder treatment have yielded disappointing results. Observational studies can complement randomized trials because they provide valuable insight into the course, treatment response, and outcomes of patients who would generally be excluded from clinical trials.
Gerard Anmella, Filippo Corponi, Bryan M. Li, Ariadna Mas, Marina Garriga, Miriam Sanabra, Isabella Pacchiarotti, Marc Valentí, Iría Grande, Antoni Benabarre, Anna Giménez‐Palomo, Isabel Agasi, Myriam Cavero, Miquel Bioque, Clemente García‐Rizo, Santiago Madero, Néstor Arbelo, Andréa Murru, Sílvia Amoretti, Anabel Martínez‐Arán, Victoria Ruíz, Y. Rivas, Giovanna Fico, Michele De Prisco, Vincenzo Oliva, Aleix Solanes, Joaquim Raduà, Ludovic Samalin, Allan H. Young, Antonio Vergari, Eduard Vieta, Diego Hidalgo‐Mazzei
Michael Berk, Robert M. Post, Aswin Ratheesh, Emma Gliddon, Ajeet Singh, Eduard Vieta, André F. Carvalho, Melanie M. Ashton, Lesley Berk, Sue Cotton, Patrick D. McGorry, Brisa S. Fernandes, Lakshmi N. Yatham, Seetal Dodd
Eduard Vieta, Jens M. Langosch, Maria Luísa Figueira, Daniel Souery, Elena Blasco‐Colmenares, Esteban Medina, Miriam Moreno-Manzanaro, Miguel González, Frank Bellivier
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