Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease.
Timothy G. England, Emily R. Beatty, Almas Rehman, Jaffar Nourooz‐Zadeh, Paulo Pereira, JAMES O'REILLY, Helen Wiseman, Catherine Geissler, Barry Halliwell
Serkalem Demissie, Daniel Levy, Emelia Benjamin, L. Adrienne Cupples, Jonathan P. Gardner, Alan Herbert, Masayuki Kimura, Martin G. Larson, James B. Meigs, John F. Keaney, Abraham Aviv
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