O3‐05‐05: EFFECTS OF A MULTIDOMAIN LIFESTYLE INTERVENTION ON OVERALL RISK FOR DEMENTIA: THE FINGER RANDOMIZED CONTROLLED TRIAL

Estimating the impact of lifestyle interventions on dementia prevention can be difficult when interventions start early, before onset of substantial cognitive impairment. One solution could be using tools for estimating dementia risk as potential outcome measures. The CAIDE Dementia Risk Score was the first validated tool for estimating dementia risk based on a midlife profile (score range 0-15 points). This study investigated the impact of lifestyle changes on changes in the CAIDE score during 2 years. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial in 1260 older adults at risk for cognitive decline. Participants were recruited from previous non-intervention surveys (6 sites across Finland). Inclusion criteria were age 60-77 years, CAIDE score at least 6 points based on previous data on midlife risk factors, and cognition at mean level or slightly lower than expected for age. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training and vascular risk management; n=631) or control (general health advice; n=629) groups. For these exploratory analyses, CAIDE score was calculated at baseline, 12-month and 24-month visits. A mixed-effects regression model with maximum likelihood estimation was used to investigate change in CAIDE score as a function of randomisation group, time, and group×time interaction. Analyses were adjusted for study site. Mean CAIDE score (SD) at the baseline FINGER visit was not significantly different between intervention and control groups: 7.88 (1.83) versus 7.84 (1.867) points, p=0.69. Estimated mean change (SE) in CAIDE score at 2 years was -0.32 (0.06) in the intervention group and -0.15 (0.06) in the control group. The mean difference between groups (group × time interaction) in change of CAIDE score per year was -0.08 (95%CI -0.16 to -0.004, p=0.039). The CAIDE score showed a significant intervention benefit on reducing the overall dementia risk level in FINGER trial participants. Considering that this score is based on simple cut-offs for risk factors, an important area for future development would be dementia risk estimation tools that are even more sensitive to capturing lifestyle changes.