Nutraceuticals intervention in Alzheimer's disease: From farm to pharma

Alzheimer's disease (AD) is a progressive neurodegenerative disease and a leading cause of dementia, profoundly affecting individuals worldwide. However, there are limited therapeutic approaches to treat AD, with current approaches primarily focused on providing symptomatic relief rather than halting the disease progression, highlighting the need for alternative strategies. Nutraceuticals, which are derived from natural sources, offer a promising alternative because of their multi-targeted mechanisms that modulate inflammation, oxidative stress and neurodegeneration, addressing key symptoms of AD pathology. Studies from clinical trials state the challenges of bioavailability and efficacy of nutraceuticals. Advancements and refinements in food processing and delivery methods, along with personalized nutrition, offer a possible approach to overcome these drawbacks. Future directions rely on combination therapies incorporating nutraceuticals to enhance the bioavailability and efficacy of these compounds. This approach could pave way for innovative solutions of elevating nutraceuticals from farm to pharma that offer sustainable solutions to mitigate AD globally.