Nonradiative resonances demonstrate revolutionary technological potential in capturing incident light, enhancing localized electric field intensity, manipulating far-field scattering, and controlling nonlinear effects at the micro/nanoscale. Here, we systematically elucidate the low-loss field localization achieved through the interference of electric dipoles in nonradiative anapole modes, while bound states in the continuum (BICs), as idealized nonradiative resonant modes, exhibit perfect field localization capability. These two distinct resonant modes, though based on different physical mechanisms—symmetry-protected mode interference versus topological eigenstate confinement—jointly overcome the performance limitations of conventional radiative systems, offering a disruptive platform for light-field manipulation in ultrasensitive optical sensing. With an aim toward practical biosensing applications, these nonradiative metasurfaces with exceptional light–matter coupling characteristics can be integrated with functionalized colloidal gold and monoclonal tag antibodies, thereby constructing a hybrid immunosensing platform capable of highly selective and label-free detection of free prostate-specific antigen (f-PSA) in complex environmental matrices. Experimental results reveal a pronounced concentration-dependent response toward f-PSA, with an impressive limit of detection down to 10 pg · mL −1 . Notably, increasing the concentration of target antibodies markedly enhances the capture efficiency of f-PSA by accelerating molecular binding kinetics and promoting saturation of recognition site occupancy. These advances pave the way for next-generation biosensing platforms that combine nanophotonic field enhancement with molecular recognition for clinical diagnostics and environmental monitoring.
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