Non-Nucleoside Structures Retain Full Anti-HCMV Potency of the Dideoxy Furanopyrimidine Family

O Bidet; Christopher McGuigan; Robert Snoeck; Graciela Andreï; De Clercq Erik; Jan Balzarini

doi:10.1177/095632020401500605

Abstract

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We have recently reported that 2',3'dideoxy analogues of our exquisitely potent anti-VZV furanopyrimidine deoxynucleosides are shifted to selective anti-HCMV agents. We now find that the fully deoxygenated 2',3',5'-trideoxy analogue is fully antivirally active. This is taken as proof that these agents act by a novel non-nucleoside mechanism of action.

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Non-Nucleoside Structures Retain Full Anti-HCMV Potency of the Dideoxy Furanopyrimidine Family

Abstract

Discussion(0)

Related publications

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Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3<i>-d</i>]pyrimidin-2(3<i>H</i>)-one Base and Nucleoside Derivatives

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