NODDI Microstructural Abnormalities in Normal-Appearing Gray Matter and White Matter Contribute to Cognitive Impairment in Multiple Sclerosis (P14-4.002)

Using neurite orientation dispersion and density imaging (NODDI), a multi-compartment diffusion model to better evaluate the complexity of brain neuroanatomical microarchitecture, we aimed to explore the associations between microarchitecture abnormalities of focal lesions and normal-appearing (NA) tissues and cognitive impairment in multiple sclerosis (MS) patients.