NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT
Article 2015 en
Authors
MK
Mobin Karimi
JB
Jerrod L. Bryson
LR
Lee P. Richman
Abstract
1 min read
Key Points NKG2D enhances cytotoxicity and survival of CD8+ T cells, which contributes to GVHD and GVT effects after allogeneic HSCT. The temporally distinct expression pattern of NKG2D ligands may allow separation of GVHD and GVT effects by transient NKG2D blockade.
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