Nicotinamide for the treatment of heart failure with preserved ejection fraction

Mahmoud Abdellatif; Viktoria Trummer-Herbst; Franziska Koser; Sylvère Durand; Rui Adão; Francisco Vasques‐Nóvoa; Johanna K. Freundt; Julia Voglhuber; María Rosaria Pricolo; Michael Kasa; Clara Türk; Fanny Aprahamian; Elías Herrero‐Galán; Sebastian J. Hofer; Tobias Pendl; Lavinia Rech; Julia Kargl; Nathaly Anto-Michel; Senka Ljubojević-Holzer; Julia Schipke; Christina Brandenberger; Martina Auer; Renate Schreiber; Chintan N. Koyani; Ákos Heinemann; Andreas Zirlik; Albrecht Schmidt; Dirk von Lewinski; Douglas S. Scherr; Peter P. Rainer; Julia von Maltzahn; Christian Mühlfeld; Marcus Krüger; Saša Frank; Frank Madeo; Tobias Eisenberg; Andreas Prokesch; Adelino Leite‐Moreira; André P. Lourenço; Jorge Alegre‐Cebollada; Stefan Kiechl; Wolfgang A. Linke; Guido Guido Kroemer; Simon Sedej

doi:10.1126/scitranslmed.abd7064

Abstract

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The NAD + precursor nicotinamide improves diastolic dysfunction caused by aging, hypertension, or metabolic syndrome in rodents.

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