Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

Nicholas Allen; Andrew Martin; Victoria A. Snaidr; Renee Eggins; Alvin H Chong; Pablo Fernández‐Peñas; Douglas L. Gin; Shireen Sidhu; Vanessa L. Paddon; Leith Banney; Adrian Lim; Edward Upjohn; Helmut Schaider; Aparna D. Ganhewa; Jennifer Nguyen; Catriona McKenzie; Saurabh Prakash; Catriona McLean; Alistair Lochhead; Jan Ibbetson; Andrew Dettrick; Anthony Landgren; Katherine J. Allnutt; Clare Allison; Rachael Davenport; Blake P. Mumford; Brittany Wong; Brendan Stagg; Alexander Tedman; Hannah Gribbin; Harrison A. Edwards; Nicholas De Rosa; T. D. Stewart; Brent J. Doolan; Yonatan Kok; Kate Simpson; Zhi M. Low; Tom Kovitwanichkanont; Richard A Scolyer; Haryana M. Dhillon; Janette L. Vardy; Steven J. Chadban; David G. Bowen; Andrew C. Chen; Diona L. Damian

doi:10.1056/nejmoa2203086

Abstract

1 min read

In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients. (Funded by the National Health and Medical Research Council; ONTRANS Australian New Zealand Clinical Trials Registry number, ACTRN12617000599370.).

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