NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis

Ian M. Berke; Era Jain; Burçin Yavuz; Thomas McGrath; L. Chen; Matthew J. Silva; Gabriel Mbalaviele; Farshid Guilak; David Kaplan; Lori A. Setton

doi:10.1016/j.joca.2020.10.008

Abstract

1 min read

These findings underscore the development of behavioral changes in this non-invasive loading model of PTOA and their relationships to NF-κB activation and pathology. They also highlight the potential chondroprotective effects of NF-κB inhibition shortly following joint injury despite limitations in preventing the long-term development of joint degeneration in this model of PTOA.

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NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis

Abstract

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