There were an estimated 536,000 maternal deaths in the world in 2005, of which 533,000 (99%) occurred in developing countries [1]. Maternal and perinatal conditions are a major contributor to the global burden of disease, yet the pipeline of new drugs specifically for maternal health is alarmingly small [2]. Only 17 drugs are under active development for maternal health indications—less than 3% of the pipeline in cardiovascular health. Since the disaster of thalidomide 50 years ago, the medical profession has been rightfully very cautious about giving newly developed drugs to pregnant women, for fear that they might damage the unborn baby. Particular caution has been exercised in the first trimester to avoid teratogenicity during organogenesis.
Maria Carolina Borges, Gemma Clayton, Rachel M. Freathy, Janine F. Felix, Alba Fernández‐Sanlés, Ana Luiza G. Soares, Fanny Kilpi, Qian Yang, Rosemary McEachan, Rebecca C. Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T. Hattersley, Barbara Bodinier, Denise Scholtens, Ellen A. Nøhr, Tom A. Bond, M. Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard, Mario Murcia, Mariona Bustamante, Marc Chadeau‐Hyam, Paul M Ridker, Martine Vrijheid, Patrice Perron, Per Magnus, Romy Gaillard, Vincent W. V. Jaddoe, William L. Lowe, Bjarke Feenstra, Marie‐France Hivert, Thorkild I. A. Sørensen, Siri E. Håberg, Sylvain Serbert, Maria C. Magnus, Debbie A. Lawlor
Maria Carolina Borges, Gemma Clayton, Rachel M. Freathy, Janine F. Felix, Alba Fernández‐Sanlés, Ana Luiza G. Soares, Fanny Kilpi, Qian Yang, Rosemary McEachan, Rebecca C. Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T. Hattersley, Barbara Bodinier, Denise Scholtens, Ellen A. Nøhr, Tom A. Bond, M. Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard,
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