New EMBO Member's Review IKKa, a critical regulator of epidermal differentiation and a suppressor of skin cancer

Pascal Descargues; Alok Kumar Sil; Michael Karin

Abstract

1 min read

IjB kinase a (IKKa), one of the two catalytic subunits ofthe IKK complex involved in nuclear factor jB (NF-jB)activation, also functions as a molecular switch that con-trols epidermal differentiation. This unexpected functionrequires IKKa nuclear translocation but does not dependon its kinase activity, and is independent of NF-jB signal-ling. Ikka

Related publications

Article2006

TAK1 Is a Master Regulator of Epidermal Homeostasis Involving Skin Inflammation and Apoptosis

Emily Omori, Kunihiro Matsumoto, Hideki Sanjo, Shintaro Sato, Akira Shizuo, Robert C. Smart, Jun Ninomiya‐Tsuji

Journal of Biological Chemistry

Article2005

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

Maria Grazia Ruocco, Shin Maeda, Jin Mo Park, Toby Lawrence, Li‐Chung Hsu, Yixue Cao, Georg Schett, Erwin F. Wagner, Michael Karin

Letter2007

Inhibitor-κB Kinase in Tumor Promotion and Suppression During Progression of Squamous Cell Carcinoma

Carter Van Waes, Ming Yu, Liesl Nottingham, Michael Karin

Article2008

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway

Ryoko Yoshida, Giichi Takaesu, Hideyuki Yoshida, Fuyuki Okamoto, Tomoko Yoshioka, Yongwon Choi, Akira Shizuo, Taro Kawai, Akihiko Yoshimura, Takashi Kobayashi

Journal of Biological Chemistry

Article2004

Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of κB Kinase α

Michelle Chaisson, Daniel Branstetter, Jonathan M.J. Derry, Allison Armstrong, Mark Tometsko, Kiyoshi Takeda, Akira Shizuo, William C. Dougall

Journal of Biological Chemistry

New EMBO Member's Review IKKa, a critical regulator of epidermal differentiation and a suppressor of skin cancer

Abstract

Discussion(0)

Related publications

TAK1 Is a Master Regulator of Epidermal Homeostasis Involving Skin Inflammation and Apoptosis

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

Inhibitor-κB Kinase in Tumor Promotion and Suppression During Progression of Squamous Cell Carcinoma

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway

Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of κB Kinase α