New Analogs of Acyclovir Substituted at the Side Chain

Zofia Jahnz‐Wechmann; Jerzy Boryski; Kunisuke Izawa; Tomoyuki Onishi; Johan Neyts; De Clercq Erik

doi:10.1080/15257770701506442

Abstract

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A series of novel analogs of acyclovir, substituted with an alkyl (methyl, ethyl, n-butyl) or phenyl group at the positions 1', 4', and/or 5', has been obtained in a direct one-pot coupling reaction of guanosine and the respective 1,3-dioxolanes. The new acyclonucleosides were essentially inactive in antiviral (HSV, VV, VSV, HBV) evaluation in vitro.

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