Nephrotoxicity of ioxaglate and ioversol assessed by glomerular filtration rate: a pilot study.

A decrease in GFR occurred more often with ioxaglate than with ioversol and usually occurred in patients with additional risk factors. Injection of contrast medium into the abdominal aorta or the renal artery may increase the risk of nephrotoxicity. Changes in serum level of creatinine at 24 hours were not reliable in identifying patients with decreased GFR. On the basis of these data, the authors estimate that a group of 194 patients would be necessary for a randomized trial comparing the nephrotoxicity of ioxaglate and ioversol for abdominal aortography.