Tumor samples most often comprise a mixture of different cell lineages. Multiregional trees built from bulk mutational profiles do not consider this heterogeneity and can potentially lead to erroneous evolutionary inferences, including biased timing of somatic mutations, spurious parallel mutation events, and/or incorrect chronological ordering of metastatic events.
Arjen Joosse, Augustinus P. T. van der Ploeg, Lauren E. Haydu, Tamar Nijsten, Esther de Vries, Richard A Scolyer, Alexander M.M. Eggermont, J.W.W. Coebergh, John F. Thompson
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