Multiple marker approach to risk stratification in patients with stable coronary artery disease

Renate B. Schnabel; Andreas Schulz; Claudia‐Martina Messow; Edith Lubos; Philipp S. Wild; Tanja Zeller; Christoph Sinning; Hans J. Rupprecht; Christoph Bickel; D Peetz; François Cambien; Tibor Kempf; Kai C. Wollert; Emelia Benjamin; Karl J. Lackner; Thomas F. Münzel; Laurence Tiret; Ramachandran S. Vasan; Stefan Blankenberg

doi:10.1093/eurheartj/ehq322

Abstract

1 min read

comparative analysis of 12 biomarkers revealed Nt-proBNP, GDF-15, MR-proANP, cystatin C, and MR-proADM as the strongest predictors of cardiovascular outcome in stable angina. All five biomarkers taken separately offered incremental predictive ability over established risk factors. Combination of the single markers slightly improved model fit but did not enhance risk prediction from a clinical perspective.

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