Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury

Finian Keleher; Hannah M. Lindsey; Rebecca Kerestes; Houshang Amiri; Robert F. Asarnow; Talin Babikian; Brenda Bartnik‐Olson; Erin D. Bigler; Karen Caeyenberghs; Carrie Esopenko; Linda Ewing‐Cobbs; Christopher C. Giza; Naomi J. Goodrich‐Hunsaker; Cooper B. Hodges; Kristen R. Hoskinson; Andrei Irimia; Marsh Königs; Jeffrey E. Max; Mary R. Newsome; Alexander Olsen; Nicholas P. Ryan; Adam Schmidt; Dan Joseph Stein; Stacy J. Suskauer; Ashley L. Ware; Anne L. Wheeler; Brandon A. Zielinski; Paul M. Thompson; Ian H. Harding; David F. Tate; Elisabeth A. Wilde; Emily L. Dennis

doi:10.1001/jamanetworkopen.2023.43410

Abstract

1 min read

In this cohort study of pediatric msTBI, our results demonstrated robust cerebellar volume alterations associated with pediatric TBI, localized to the posterior lobe. Furthermore, longitudinal cerebellum changes were associated with baseline diffusion tensor MRI metrics, suggesting secondary cerebellar atrophy. These results provide further understanding of secondary injury mechanisms and may point to new opportunities for intervention.

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