The presence of normal-appearing brain tissue (NABT) changes was investigated in 30 first-degree relatives of patients with MS, using magnetization transfer ratio (MTR) histograms. When compared with controls, relatives of patients with familial (p = 0.01) and sporadic (p = 0.01) MS had lower NABT MTR histogram peak heights. This study suggests a reduction of truly normal NABT in asymptomatic relatives of patients with MS.
Marco Rovaris, Elda Judica, Jaume Sastre‐Garriga, Àlex Rovira, Maria Pia Sormani, Béatrice Benedetti, Tijmen Korteweg, Nicola De Stefano, Zhaleh Khaleeli, Xavier Montalbán, Frederik Barkhof, David H. Miller, Chris H. Polman, Alan J. Thompson, Massimo Filippi
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