MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage

Ghil Schwarz; Gargi Banerjee; Isabel C. Hostettler; Gareth Ambler; David Seiffge; Hatice Özkan; Simone Browning; Robert Simister; Duncan Wilson; Hannah Cohen; Tarek Yousry; Rustam Al‐Shahi Salman; Professor Gregory Lip; Martin M. Brown; Keith W. Muir; Henry Houlden; Hans Rolf Jäger; David J. Werring

doi:10.1177/17474930211062478

Abstract

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In lobar ICH survivors, we found associations between putative biomarkers of parenchymal CAA (FLP and strictly lobar CMBs) and putative biomarkers of leptomeningeal CAA (SAE and cSS). In a hospital population, CT biomarkers might help rule-in probable CAA (diagnosed using the Boston criteria), but their absence is probably not as useful to rule it out, suggesting an important continued role for MRI in ICH survivors with suspected CAA.

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George Perry