This review motivates and synthesizes research efforts in neuroscience-inspired artificial intelligence and biomimetic computing in terms of mortal computation. Specifically, we characterize the notion of mortality by recasting ideas in biophysics, cybernetics, and cognitive science in terms of a theoretical foundation for sentient behavior. We frame the mortal computation thesis through the Markov blanket formalism and the circular causality entailed by inference, learning, and selection. The ensuing framework -- underwritten by the free energy principle -- could prove useful for guiding the construction of unconventional connectionist computational systems, neuromorphic intelligence, and chimeric agents, including sentient organoids, which stand to revolutionize the long-term future of embodied, enactive artificial intelligence and cognition research.
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