A series of 2-arylidene-1-indanones, 1, had been shown previously to display cytotoxic properties towards Molt 4/C8, CEM and L1210 cells. In the present study, two series of analogues of 1 were prepared namely various 2-arylidene-1,3-indandiones, 2, and chalcones, 3. In general, the potencies of compounds 2 and 3 were greater than the analogues bearing the same aryl substituents in series 1. Molecular modeling was undertaken in order to seek explanations for the variation in bioactivities.
Jonathan R. Dimmock, Maniyan P. Padmanilayam, Umashankar Das, Gordon A. Zello, Rajendra K. Sharma, Anuraag Shrivastav, Selvakumar Palaniappan, Mohammed Khysar Pasha, Kurt H. Nienaber, Jeremy S. Lee, Theresa M. Allen, C.L. Santos, Jan Balzarini, De Clercq Erik
Jonathan R. Dimmock, N. Murthi Kandepu, Adil J. Nazarali, Travis P. Kowalchuk, Narasimhan L. Motaganahalli, J. Wilson Quail, Patricia A. Mykytiuk, Gerald F. Audette, L. Guru Prasad, Pál Perjési, Theresa M. Allen, C.L. Santos, Jen Szydlowski, De Clercq Erik, Jan Balzarini
Jonathan R. Dimmock, Maniyan P. Padmanilayam, R.N. Puthucode, Adil J. Nazarali, Narasimhan L. Motaganahalli, Gordon A. Zello, J. Wilson Quail, E.O. Oloo, Heinz‐Bernhard Kraatz, Jared S. Prisciak, Theresa M. Allen, C.L. Santos, Jan Balzarini, De Clercq Erik, Elias K. Manavathu
Jonathan R. Dimmock, Gordon A. Zello, E.O. Oloo, J. Wilson Quail, Heinz‐Bernhard Kraatz, Pál Perjési, F. Aradi, Krisztina Takács‐Novák, Theresa M. Allen, C.L. Santos, Jan Balzarini, De Clercq Erik, James P. Stables
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