Molecular imaging of Cyclin E1 represents an indicator of acute and chronic liver disease
Article 2015 de
Authors
RS
Roland Sonntag
FH
Felix Heymann
MM
Marsha K. Mertens
Abstract
1 min read
Acute and chronic liver diseases are frequently associated with proliferation of Hepatocytes and Hepatic stellate cells (HSC). The proliferation of immune cells in this context is poorly investigated. Sustained activation of these processes can lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). E-cyclins (E1, E2) control transition into S-phase of the cell cycle and play a crucial role during carcinogenesis. Our own preliminary work demonstrated an essential role of Cyclin E1 for liver fibrogenesis and HCC development in mice. Thus Cyclin E1 could be a suitable diagnostic marker for indication of liver fibrosis and HCC. The aim of the present study was to develop novel strategies for early diagnosis of aberrant Cyclin E1 expression and identification of novel Cyclin E1 expressing cell populations in liver fibrosis and HCC.
Yulia A. Nevzorova, Jörg‐Martin Bangen, Wei Hu, Ute Haas, Ralf Weiskirchen, Nikolaus Gaßler, Sebastian Huss, Frank Tacke, Piotr Siciński, Christian Trautwein, Christian Liedtke
Julia Otto, Anna Verwaayen, Christian Penners, Jana Hundertmark, Cheng Lin, Carina Kallen, Daniela Paffen, Tobias Otto, Hilmar Berger, Frank Tacke, Ralf Weiskirchen, Yulia A. Nevzorova, Matthias Bartneck, Christian Trautwein, Roland Sonntag, Christian Liedtke
Roland Sonntag, Nives Giebeler, Yulia A. Nevzorova, Jörg‐Martin Bangen, Dirk Fahrenkamp, Daniela Lambertz, Ute Haas, Wei Hu, Nikolaus Gaßler, Francisco Javier Cubero, Gerhard Müller‐Newen, Ali T. Abdallah, Ralf Weiskirchen, Fabio Ticconi, Ivan G. Costa, Mariano Barbacid, Christian Trautwein, Christian Liedtke
Discussion(0)
No comments yet. Be the first to comment.