Molecular imaging of Cyclin E1 represents an indicator of acute and chronic liver disease

Acute and chronic liver diseases are frequently associated with proliferation of Hepatocytes and Hepatic stellate cells (HSC). The proliferation of immune cells in this context is poorly investigated. Sustained activation of these processes can lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). E-cyclins (E1, E2) control transition into S-phase of the cell cycle and play a crucial role during carcinogenesis. Our own preliminary work demonstrated an essential role of Cyclin E1 for liver fibrogenesis and HCC development in mice. Thus Cyclin E1 could be a suitable diagnostic marker for indication of liver fibrosis and HCC. The aim of the present study was to develop novel strategies for early diagnosis of aberrant Cyclin E1 expression and identification of novel Cyclin E1 expressing cell populations in liver fibrosis and HCC.