Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

Jeff Linnen; J. Wages; Z Y Zhang-Keck; Kirk E. Fry; K. Krawczyński; Harvey J. Alter; Eugene V Koonin; Margaret Gallagher; Miriam J. Alter; Stephanos J. Hadziyannis; Peter Karayiannis; Kevin Fung; Yoshiyuki Nakatsuji; J. Wai‐Kuo Shih; L M Young; Michael Piatak; Cameron Hoover; John Fernandez; Stacie Chen; Jian-Chao Zou; Timothy T. Morris; Kenneth C. Hyams; S. Ismay; Jeffrey D. Lifson; Georg Heß; Steven K. H. Foung; Howard Thomas; Daniel W. Bradley; Harold S. Margolis; Jungsuh P. Kim

doi:10.1126/science.271.5248.505

Abstract

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An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

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Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

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