Molecular classification of hepatocellular carcinoma based on zoned metabolic feature and oncogenic signaling pathway
Article 2025 en
Authors
TA
Tomoko Aoki
NN
Naoshi Nishida
YK
Yutaka Kurebayashi
Abstract
1 min read
The loss of liver-specific metabolism correlates with morphological dedifferentiation, indicating cellular dedifferentiation may exhibit both physiological and pathological duality. Key signaling pathways involved in the maturation process from fetal to adult liver and zonation program may play a critical role in defining HCC diversity.
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