Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas.

Fernando Gallardo; Manel Esteller; Ramón M. Pujol; Carlota Costa; Teresa Estrach; Octavio Servitje

Abstract

1 min read

p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.

Discussion(0)

No comments yet. Be the first to comment.

Related publications

Article2004

Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia.

Davide Rossi, Daniela Capello, Annunziata Gloghini, Silvia Franceschetti, Marco Paulli, Kishor Bhatia, Giuseppe Saglio, Umberto Vitolo, Stefano Pileri, Manel Esteller, Antonino Carbone, Gianluca Gaïdano

Article2001

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

Manel Esteller, James G. Herman

Article1999

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Manel Esteller, Stanley R. Hamilton, P C Burger, S B Baylin, James G. Herman

Article2013

Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer

Alessio Amatu, Andrea Sartore‐Bianchi, Cátia Moutinho, Alessandro Belotti, Katia Bencardino, Giuseppe Chirico, Andrea Cassingena, Francesca Rusconi, Anna Esposito, Michele Nichelatti, Manel Esteller, Salvatore Siena

Article2000

Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.

Montse Sánchez‐Céspedes, Manel Esteller, Li Wu, H Nawroz-Danish, G. Yoo, Wayne M. Koch, Jin Jen, James G. Herman, David Sidransky