Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent Plasmodium vivax and Plasmodium ovale malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.
Ihsan Fadilah, Robert J. Commons, Nguyen Hoang Chau, Cindy S. Chu, Nicholas Day, Gavin Koh, Justin A. Green, Marcus Lacerda, Alejandro Llanos‐Cuentas, Erni Juwita Nelwan, François Nosten, Ayodhia Pitaloka Pasaribu, Inge Sutanto, Walter RJ Taylor, Kamala Thriemer, Ric N. Price, Sir Nicholas White, J. Kevin Baird, James A Watson
Ihsan Fadilah, Robert J. Commons, Nguyen Hoang Chau, Cindy S. Chu, Nicholas Day, Gavin Koh, Justin A. Green, Marcus Lacerda, Alejandro Llanos‐Cuentas, Erni Juwita Nelwan, François Nosten, Ayodhia Pitaloka Pasaribu, Inge Sutanto, Walter Taylor, Kamala Thriemer, Ric N. Price, Sir Nicholas White, J. Kevin Baird, James A Watson
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