Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines.

9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] did not undergo metabolic changes in any of the eleven cell lines tested. In these, it exhibited a varying antiviral activity against vesicular stomatitis virus (VSV), which appeared to correlate with the relative amounts of (S)-DHPA that had become cell-associated during virus infection.