Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis

Segun Fatumo; Ville Karhunen; Tinashe Chikowore; Toure Sounkou; Brenda Udosen; Chisom Ezenwa; Mariam Nakabuye; Opeyemi Soremekun; Iyas Daghlas; David Ryan; Amybel Taylor; Amy M. Mason; Scott M. Damrauer; Marijana Vujković; Keith L. Keene; Myriam Fornage; Paul M Ridker; Stephen Burgess; Dipender Gill

doi:10.1161/strokeaha.121.034747

Abstract

1 min read

Metabolic traits affect ischemic stroke (IS) risk, but the degree to which this varies across different ethnic ancestries is not known. Our aim was to apply Mendelian randomization to investigate the causal effects of type 2 diabetes (T2D) liability and lipid traits on IS risk in African ancestry individuals, and to compare them to estimates obtained in European ancestry individuals.

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