Meta-Analysis of the Immunogenicity and Tolerability of Pandemic Influenza A 2009 (H1N1) Vaccines

Lamberto Manzoli; Corrado De Vito; Georgia Salanti; M D’Addario; Paolo Villari; John P A Ioannidis

doi:10.1371/journal.pone.0024384

Abstract

1 min read

Several one-dose formulations might be valid for future vaccines, but 2 doses may be needed for children, especially if a low-dose non-adjuvanted vaccine is used. Given that 15 RCTs were sponsored by vaccine manufacturers, future trials sponsored by non-industry agencies and comparing vaccines using different types of adjuvants are needed.

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