Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells

Klarissa Hollander; Swapnil C. Devarkar; Su Tang; Ritudhwaj Tiwari; Shumeng Ma; Won‐Gil Lee; Elizabeth R Denn; Qiankun Wang; Krasimir A. Spasov; J. Robbins; Kathleen M. Frey; William L. Jorgensen; Yong Xiong; Liang Shan; Karen S. Anderson

doi:10.1038/s44386-025-00025-2

Related publications

Article1996

A novel function for Myc: inhibition of C/EBP-dependent gene activation.

Sigrun Mink, Bettina Mutschler, Ralf Weiskirchen, Klaus Bister, Karl‐Heinz Klempnauer

Article2021

Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product

Gengxiang Zhao, Dalibor Košek, Hongbing Liu, Shannon I. Ohlemacher, Brittney Blackburne, A. N. NIKOL'SKAYA, Kira S. Makarova, Jiadong Sun, Clifton E. Barry, Eugene V Koonin, Fred Dyda, Carole A. Bewley

Article2023

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators

Shujing Xu, Lin Sun, Michael J. Barnett, Xujie Zhang, Dang Ding, Anushka Gattu, Dazhou Shi, Jamie R. H. Taka, Wenli Shen, Xiangyi Jiang, Simon Cocklin, De Clercq Erik, Christophe Pannecouque, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan

Article2015

A novel transcript variant of proteasome activator 28γ: Identification and function in oral cancer cells

Xiaoping Xu, Dongjuan Liu, Ning Ji, Taiwen Li, Longjiang Li, Lu Jiang, Jing Li, Ping Zhang, Xin Zeng, Qianming Chen

International Journal of Oncology

Article2002

A Human Immunodeficiency Virus Type 1 Isolate from an Infected Person Homozygous for CCR5Δ32 Exhibits Dual Tropism by Infecting Macrophages and MT2 Cells via CXCR4

Hassan M. Naif, Anthony L. Cunningham, Mohammed Alali, Shan Li, Najla Nasr, Marc McW Buhler, Dominique Schols, De Clercq Erik, Graeme J. Stewart