Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

Jenny Sprooten; Isaure Vanmeerbeek; Angeliki Datsi; Jannes Govaerts; Stefan Naulaerts; Raquel S. Laureano; Daniel Borràs; Anna Calvet; Vanshika Malviya; Marc Kuballa; Jörg Felsberg; Michael Sabel; Marion Rapp; Christiane B. Knobbe‐Thomsen; Peng Liu; Liwei Zhao; Oliver Kepp; Louis Boon; Sabine Tejpar; Jannie Borst; Guido Guido Kroemer; Susan Schlenner; Steven De Vleeschouwer; Rüdiger V. Sorg; Abhishek D. Garg

doi:10.1016/j.xcrm.2023.101377

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Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

Abstract

Discussion(0)

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A lymph node-to-tumour PDL1<sup>+</sup>macrophage circuit antagonizes dendritic cell immunotherapy

Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Data from Early Detection of Tumor Cells by Innate Immune Cells Leads to T<sub>reg</sub> Recruitment through CCL22 Production by Tumor Cells

Data from Early Detection of Tumor Cells by Innate Immune Cells Leads to T<sub>reg</sub> Recruitment through CCL22 Production by Tumor Cells

Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

Abstract

Discussion(0)

Related publications

A lymph node-to-tumour PDL1<sup>+</sup>macrophage circuit antagonizes dendritic cell immunotherapy

Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Data from Early Detection of Tumor Cells by Innate Immune Cells Leads to T&lt;sub&gt;reg&lt;/sub&gt; Recruitment through CCL22 Production by Tumor Cells

Data from Early Detection of Tumor Cells by Innate Immune Cells Leads to T&lt;sub&gt;reg&lt;/sub&gt; Recruitment through CCL22 Production by Tumor Cells

Data from Early Detection of Tumor Cells by Innate Immune Cells Leads to T<sub>reg</sub> Recruitment through CCL22 Production by Tumor Cells

Data from Early Detection of Tumor Cells by Innate Immune Cells Leads to T<sub>reg</sub> Recruitment through CCL22 Production by Tumor Cells